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About Imiquad® Cream

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Imiquad® Cream is manufactured by Glenmark. This is a topical immunomodulatory medication used to treat certain viral and cancer-associated skin conditions.

Imiquad® Cream comprises Imiquimod as an active ingredient. It is an immune response modifier. Imiquimod does not affect a disease directly, but it helps immune system in fighting the pathogen that causes a disorder.


- superficial pre-cancerous skin lesions (Actinic keratosis);

- cancerous skin conditions (superficial basal cell carcinoma);

- external genital viral warts.

Imiquad® Cream also can be indicated for an off-label treatment of nodular basal cell carcinoma, non-genital viral warts, molluscum contagiosum, keloid scarring, melanoma metastases, Bowen’s disease, actinic porokeratosis, cutaneous T-cell lymphoma, vulval intra-epithelial neoplasia, extra-mammary Paget’s disease, lentigo maligna.

MOA (mechanism of action):

When pathogens such as viruses, bacteria, and tumor cells invade the body, Imiquimod acts as a TLR7 (toll-like receptor 7) agonist and induces certain cytokines including interferon-alpha proteins. These proteins are important in cell signaling and recognition of harmful substances. After a harmful invader is recognized, immune system responds to it with inflammation aimed at ruining the pathogen. Imiquimod also may increase the infiltration of lymphocytes, dendritic cells, and macrophages into the tumor lesion.


For external genital viral warts: apply 3 times a week (every second day) and leave for 6-10 hours, do not shower or bathe during this time. Treatment is required for 8 weeks for women and 12 weeks for men.

For basal cell carcinoma: apply 5 times a week (5 times in a row with a two-day break) and leave for 8 hours, do not shower or bathe during this time. Treatment is required during 6 weeks.

For actinic keratosis: apply 3 times a week (every second day) and leave for 8 hours, do not shower of bathe during this time. Treatment is required for 4 weeks. If lesions have not cured, the course might be prolonged for 4 weeks more.

It is recommended to apply Imiquad® Cream at bedtime and wash it off in the morning.

Wash your hands before and after using Imiquad® Cream. Always clean the treated area before applying the cream.

Cut a corner of the sachet, squeeze some cream onto your finger and apply it to the treated area.

Apply some cream on about a centimeter of healthy skin around the affected area.

Imiquad® Cream is for topical use only. Do not apply Imiquad® Cream in the uretra, cervix, vagina, and anus.

Do not use Imiquad® Cream in patients under 12 years old.

Do not use Imiquad® Cream for more than 16 weeks.

Do not cover the application site with a bandages or other dressing right after applying Imiquad® Cream.

Consult your doctor on how often to apply Imiquad® Cream. Use Imiquad® Cream exactly as directed.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not apply a double dose.


Do not exceed the doctor's recommended dose. If an overdose occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately.


Store at a room temperature from 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away the tube after the expiration date. Keep away from children.

Side effects

The most common side effects associated with the use of Imiquad® Cream:

  • changes in skin color at the application site
  • lowering of blood counts
  • redness, swelling, itching, and burning at the application site
  • hardening of the skin
  • headache
  • joint and muscle pains
  • prolapse of the womb
  • erection difficulties
  • sweating
  • dizziness and ringing in the ears
  • tiredness
  • nausea and loss of appetite
  • swollen glands
  • bacterial, viral, and fungal infections (e.g. cold sores)
  • vaginal infection including thrush
  • anorexia

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.


Do not apply Imiquad® Cream if you are allergic to Imiquimod or any other immunomodulator.

Do not apply Imiquad® Cream if you are allergic to any of the other ingredients comprised in Imiquad® Cream.

Do not apply Imiquad® Cream if you have a history of severe allergic reactions associated with using immune response modifiers.

Do not apply Imiquad® Cream if you have a weakened immune system, an autoimmune disorder (e.g., rheumatoid arthritis, lupus), or human papilloma virus (HPV) infection.

Do not apply Imiquad® Cream if your skin has not completely healed from surgery or other types of treatment.

Do not use Imiquad® Cream in patients under 12 years old.

Imiquad® Cream is for topical use only. Dot apply into eyes, nose, mouth, anus, vagina, cervix or urethra. If it does get there, wash with water and mild soap. Do not swallow.

Do not use Imiquad® Cream for more than one course if you have problems with your immune system.

If you are HIV positive, consult your doctor prior to start the Imiquad® Cream treatment course.

Do not leave Imiquad® Cream on the skin before sexual activity, as it may weaken condoms or diaphragms.

Do not cover treated skin areas with a bandage or other covering while using Imiquad® Cream, as covering may increase the amount of medication absorbed into skin and cause undesirable side effects.

Avoid sunlight as much as possible during treatment with Imiquad® Cream.

Do not use Imiquad® Cream if it has already expired.

Inform your doctor if you are pregnant. Imiquad® Cream should be used during pregnancy only if clearly needed.

Do not use Imiquad® Cream if you are breastfeeding.

Do not apply Imiquad® Cream more than once a day.

Q: Can I use Imiquad® Cream for my child?

A: Imiquad® Cream cannot be used in patients under 12 years old.

Q: Is Imiquad® Cream a steroid drug?

A: No. Imiquad® Cream is an immune response modifier.

Q: Is it safe to breastfeed during Imiquad® Cream treatment course?

A: You should not breastfeed during the use of Imiquad® Cream, since it is not known whether this medication transmits into breast milk.

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